Visual Field Severity Indices Demonstrate Dose-Dependent Visual Loss from Vigabatrin Therapy

Visual field defects associated with vigabatrin therapy.

OBJECTIVE To estimate the prevalence of visual field defects in patients taking the anticonvulsant drug vigabatrin and to characterise the features of visual dysfunction found. METHODS Thirty three unselected patients attending neurology and epilepsy clinics were identified as taking vigabatrin and asked to attend for neuro-ophthalmic evaluation. A control group of 16 patients with epilepsy u...

Visual field loss associated with vigabatrin: pathological correlations.

Pathological changes are reported in the anterior visual pathways of a 41 year old man with complex partial seizures treated with vigabatrin who developed bilateral visual field constriction. There was peripheral retinal atrophy with loss of ganglion cells and loss of nerve fibres in the optic nerves, chiasm, and tracts. No evidence of intramyelinic oedema was seen. These findings suggest that ...

Coleman of vigabatrin induced visual field defects

http://bjo.bmj.com/content/86/8/931.full.html Updated information and services can be found at: These include: References http://bjo.bmj.com/content/86/8/931.full.html#ref-list-1 This article cites 3 articles, 2 of which can be accessed free at: service Email alerting the top right corner of the online article. Receive free email alerts when new articles cite this article. Sign up in the box at...

Vigabatrin and Visual Field Defects in Pediatric Epilepsy Patients

We studied the prevalence, type and severity of vigabatrin (VGB)-attributed visual field defects (VFDs), and used these data to assess the associated risk factors in pediatric patients. Medical records were retrospectively reviewed for 67 pediatric patients who received VGB alone or in combination with other antiepileptic drugs, and who had undergone visual field examinations using a Humphrey v...

Vigabatrin-associated Visual Field Loss (vavfl): What You Need to Know